Molecular mechanism of cell death induced by chemotherapeutic agents

研究成果: Review article査読

抄録

Cells maintain their homeostasis by checkpoint mechanisms that exist at each phase of the cell cycle. Impairment of the checkpoint mechanisms induces DNA mutation and asymmetric segregation of chromosomes, which result in genomic instability, leading to malignant cell transformation. DNA-damaging agents, which are still the first-line chemotherapeutic drugs for various cancers, have recently been demonstrated to induce death in cancer cells alone just because these cells have abnormalities in their checkpoint mechanisms. The mitotic checkpoint, in particular, has been found to play a key role in the drug-induced cell death. An understanding of the molecular mechanisms of chemotherapy will enable us to use conventional drugs more appropriately for cancer treatment.

本文言語English
ページ(範囲)843-847
ページ数5
ジャーナルBrain and Nerve
61
7
出版ステータスPublished - 2009 7 1

ASJC Scopus subject areas

  • 臨床神経学

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