TY - JOUR
T1 - Molecular mechanisms and drug development in aquaporin water channel diseases
T2 - Structure and function of aquaporins
AU - Yasui, Masato
PY - 2004/11
Y1 - 2004/11
N2 - The discovery of the water channel aquaporin has greatly expanded our understanding of the regulation of the water permeability of biological membranes. The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders. Eleven mammalian aquaporins have been identified, each with a distinct distribution, and these are selectively permeated by water or water plus glycerol. Aquaporins are suspected in numerous pathological conditions involving fluid transport such as brain edema. Knowledge of aquaporin structure may provide insight into the development of new therapeutics through appropriate drug design.
AB - The discovery of the water channel aquaporin has greatly expanded our understanding of the regulation of the water permeability of biological membranes. The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders. Eleven mammalian aquaporins have been identified, each with a distinct distribution, and these are selectively permeated by water or water plus glycerol. Aquaporins are suspected in numerous pathological conditions involving fluid transport such as brain edema. Knowledge of aquaporin structure may provide insight into the development of new therapeutics through appropriate drug design.
KW - Aquaporin-1
KW - Human disease
KW - Permeability
KW - Structure and function
KW - Water channel
UR - http://www.scopus.com/inward/record.url?scp=10944262720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10944262720&partnerID=8YFLogxK
U2 - 10.1254/jphs.FMJ04004X4
DO - 10.1254/jphs.FMJ04004X4
M3 - Short survey
C2 - 15557734
AN - SCOPUS:10944262720
VL - 96
SP - 260
EP - 263
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
SN - 1347-8613
IS - 3
ER -