Molecular mechanisms and drug development in aquaporin water channel diseases: Structure and function of aquaporins

研究成果: Short survey査読

41 被引用数 (Scopus)

抄録

The discovery of the water channel aquaporin has greatly expanded our understanding of the regulation of the water permeability of biological membranes. The atomic structure of aquaporin-1 (AQP1) demonstrated how aquaporin is freely permeated by water but not protons and provided marked insight into several human disorders. Eleven mammalian aquaporins have been identified, each with a distinct distribution, and these are selectively permeated by water or water plus glycerol. Aquaporins are suspected in numerous pathological conditions involving fluid transport such as brain edema. Knowledge of aquaporin structure may provide insight into the development of new therapeutics through appropriate drug design.

本文言語English
ページ(範囲)260-263
ページ数4
ジャーナルJournal of Pharmacological Sciences
96
3
DOI
出版ステータスPublished - 2004 11
外部発表はい

ASJC Scopus subject areas

  • 分子医療
  • 薬理学

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