Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I

Nicholas P. Restifo, Yutaka Kawakami, Franco Marincola, Peter Shamamian, Akash Taggarse, Fernando Esquivel, Steven A. Rosenberg

研究成果: Article

119 引用 (Scopus)

抜粋

In this article, we explore the hypothesis that tumor cells can escape recognition by CD8+T cells via deficiencies in antigen processing and presentation. Aspects of the molecular and cellular biology of major histocompatibility complex class I are reviewed. Evidence for histology-specific molecular mechanisms in the antigen-processing and -presentation deficiencies observed in some human and murine tumors is presented. Mechanisms identified include down-regulation of antigen processing, loss of functional β2-microglobulin, and deletion of specific α-chain alleles. Finally, we discuss studies using an antigen-presentation-deficient mouse tumor as a model for the immunogenetherapy of an antigen-presentation deficiency.

元の言語English
ページ(範囲)182-190
ページ数9
ジャーナルJournal of Immunotherapy
14
発行部数3
DOI
出版物ステータスPublished - 1993 10

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology
  • Cancer Research

フィンガープリント Molecular mechanisms used by tumors to escape immune recognition: Immunogenetherapy and the cell biology of major histocompatibility complex class I' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用