Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein

Masakazu Ueda; Kyriakos Psarras; Hiromitsu Jinno; Tadashi Ikeda; Kohji Enomoto; Masaki Kitajima; Junichiro Futami; Hidenori Yamada; Masaharu Seno

doi:10.1007/BF02966516

Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein

Masakazu Ueda, Kyriakos Psarras, Hiromitsu Jinno, Tadashi Ikeda, Kohji Enomoto, Masaki Kitajima, Junichiro Futami, Hidenori Yamada, Masaharu Seno

外科学

研究成果: Article › 査読

3 被引用数 (Scopus)

抄録

Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins.

本文言語	English
ページ（範囲）	253-255
ページ数	3
ジャーナル	Breast Cancer
巻	4
号	4
DOI	https://doi.org/10.1007/BF02966516
出版ステータス	Published - 1997 12 1

ASJC Scopus subject areas

Oncology
Radiology Nuclear Medicine and imaging
Pharmacology (medical)

文献へのアクセス

10.1007/BF02966516

フィンガープリント「Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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abstract = "Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins.",

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AU - Ueda, Masakazu

AU - Psarras, Kyriakos

AU - Jinno, Hiromitsu

AU - Ikeda, Tadashi

AU - Enomoto, Kohji

AU - Kitajima, Masaki

AU - Futami, Junichiro

AU - Yamada, Hidenori

AU - Seno, Masaharu

PY - 1997/12/1

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AB - Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins.

KW - Breast cancer

KW - EGFR

KW - Fusion protein

KW - RNase

KW - Targeting

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