Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein

Masakazu Ueda, Kyriakos Psarras, Hiromitsu Jinno, Tadashi Ikeda, Kohji Enomoto, Masaki Kitajima, Junichiro Futami, Hidenori Yamada, Masaharu Seno

研究成果: Article

3 引用 (Scopus)

抄録

Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins.

元の言語English
ページ(範囲)253-255
ページ数3
ジャーナルBreast Cancer
4
発行部数4
DOI
出版物ステータスPublished - 1997 12

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Cell Fusion
Ribonucleases
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Breast Neoplasms
Proteins
Antineoplastic Agents
Squamous Cell Carcinoma
Breast
Cell Line

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

これを引用

Ueda, M., Psarras, K., Jinno, H., Ikeda, T., Enomoto, K., Kitajima, M., ... Seno, M. (1997). Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein. Breast Cancer, 4(4), 253-255. https://doi.org/10.1007/BF02966516

Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein. / Ueda, Masakazu; Psarras, Kyriakos; Jinno, Hiromitsu; Ikeda, Tadashi; Enomoto, Kohji; Kitajima, Masaki; Futami, Junichiro; Yamada, Hidenori; Seno, Masaharu.

:: Breast Cancer, 巻 4, 番号 4, 12.1997, p. 253-255.

研究成果: Article

Ueda, M, Psarras, K, Jinno, H, Ikeda, T, Enomoto, K, Kitajima, M, Futami, J, Yamada, H & Seno, M 1997, 'Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein', Breast Cancer, 巻. 4, 番号 4, pp. 253-255. https://doi.org/10.1007/BF02966516
Ueda, Masakazu ; Psarras, Kyriakos ; Jinno, Hiromitsu ; Ikeda, Tadashi ; Enomoto, Kohji ; Kitajima, Masaki ; Futami, Junichiro ; Yamada, Hidenori ; Seno, Masaharu. / Molecular targeting for epidermal growth factor receptor expressed on breast cancer cells by human fusion protein. :: Breast Cancer. 1997 ; 巻 4, 番号 4. pp. 253-255.
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