Morphological Control of Endothelial Tube Formation by Three-Dimensional Lane-Shaped Patterns

Yuki Ikezawa, Hiroaki Onoe

研究成果: Conference contribution

抄録

This paper describes an analytical platform to control endothelial tube formation by patterning cells and extracellular matrix (ECM) within 3D lane-shaped pattern. By using PDMS groove patterns (50-250\ \mu \mathrm{m} in width and height, several millimeters in length), human umbilical vein endothelial cells (HUVECs) were patterned three-dimensionally in collagen gel. The patterned HUVECs spontaneously form endothelial vascular tissues, but their morphologies can be controlled by the dimensions of patterns, cell densities, ECMs, etc. We succeeded in forming vascular tube tissues, and found that a number of branches of the vascular tissues depends on the dimensions of 3D-patterns. We believe that our culture system could be a useful tool for understanding the tube formation behavior of endothelial cells and for creating 3D-shape-controlled vascular tissues as a quantitative model in vitro.

本文言語English
ホスト出版物のタイトル2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems, MEMS 2019
出版社Institute of Electrical and Electronics Engineers Inc.
ページ594-596
ページ数3
ISBN(電子版)9781728116105
DOI
出版ステータスPublished - 2019 1月
イベント32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019 - Seoul, Korea, Republic of
継続期間: 2019 1月 272019 1月 31

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
2019-January
ISSN(印刷版)1084-6999

Conference

Conference32nd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2019
国/地域Korea, Republic of
CitySeoul
Period19/1/2719/1/31

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 機械工学
  • 電子工学および電気工学

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