Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions

Toshinori Sato, Mineo Hashizume, Yasunobu Hotta, Yoshio Okahata

研究成果: Article

38 引用 (Scopus)

抄録

The effects of trivalent metal ions such as lanthanoid (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Er3+, Yb3+, Lu3+) and Al3+ ions on the morphological change and proliferation of B16 melanoma cells in culture are discussed. These metal ions induced morphological transformations and decreased growth rates at doses of 1 mM, B16 melanoma cells treated with La3+, Ce3+, Nd3+, Sm3+, and Gd3+ showed polyhedrical spreading. Elongation of axones was dependent on the metal ions, B16 melanoma cells treated with Er3+, Yb3+, Lu3+, and Al3+ showed a long slender shape. Growth rates of melanoma cells in the presence of 1 mM of metal ions (La3+, Ce3+, Nd3+, Sm3+, Gd3+, Yb3+, Al3+) were significantly lower than that of control cells. Measurements of cell cycle indicated that the metal ions arrested the transitions from G0/G1, to S state.

元の言語English
ページ(範囲)107-112
ページ数6
ジャーナルBioMetals
11
発行部数2
DOI
出版物ステータスPublished - 1998
外部発表Yes

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Lanthanoid Series Elements
Experimental Melanomas
melanoma
metal ions
Metal ions
aluminum
Ions
ions
Metals
cells
Growth
Elongation
cell cycle
cell culture
Cells
Melanoma
Cell Cycle
Cell Culture Techniques
dosage

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions. / Sato, Toshinori; Hashizume, Mineo; Hotta, Yasunobu; Okahata, Yoshio.

:: BioMetals, 巻 11, 番号 2, 1998, p. 107-112.

研究成果: Article

Sato, Toshinori ; Hashizume, Mineo ; Hotta, Yasunobu ; Okahata, Yoshio. / Morphology and proliferation of B16 melanoma cells in the presence of lanthanoid and Al3+ ions. :: BioMetals. 1998 ; 巻 11, 番号 2. pp. 107-112.
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