Background: Helicobacter suis strain TKY infection has been strongly associated with the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in a C57BL/6J mouse model. Materials and Methods: 1. C57BL/6J mice were intragastrically administered Lactobacillus strains once daily with 108-109 colony-forming units (CFU), starting 2 days before intragastric infection with H. suis TKY (approximately 1 × 104 copies of 16S rRNA genes) or H. pylori Sydney strain 1 (SS1; 3 × 108 CFU) and continuing for 14 days after infection. 2. C57BL/6J mice were given powdered feed mixed with lyophilized L. gasseri SBT2055 (LG2055) cells (5 × 108 CFU/g), starting 2 weeks before intragastric infection with H. suis TKY and continuing 12 months after infection. Results: 1. Among the 5 Lactobacillus strains that we examined, only LG2055 exhibited significantly preventive efficacy against both H. suis TKY and H. pylori SS1 at day 15 after infection. 2. Dietary supplementation with LG2055 protected mice from the formation of round protrusive lesions in the gastric fundus 12 months after infection with H. suis TKY, whereas such lesions had developed in the gastric fundus of nonsupplemented mice 12 months after infection. In addition, the formation of lymphoid follicles in gastric mucus layers was suppressed by dietary LG2055 at 3 months after infection. Conclusions: LG2055 administration is effective for suppressing the progression of gastric MALT lymphoma by reducing H. suis colonization.
ASJC Scopus subject areas
- Infectious Diseases