Mouse myocilin (Myoc) gene expression in ocular tissues

Hiroki Takahashi, Setsuko Noda, Yutaka Imamura, Akemi Nagasawa, Ryo Kubota, Yukihiko Mashima, Jun Kudoh, Yoshihisa Oguchi, Nobuyoshi Shimizu

研究成果: Article査読

41 被引用数 (Scopus)

抄録

Human myocilin is identical to TIGR (trabecular meshwork inducible glucocorticoid response) which is responsible for the pathogenesis of juvenile-onset primary open angle glaucoma (GLC1A). We have isolated cDNA for mouse myocilin (Myoc) and investigated mouse myocilin gene expression in ocular tissues with in situ RNA hybridization. Hybridization signals were observed in the iris, ciliary body, trabecular meshwork, sclera, and retina in the mouse eye. The marked signals were seen in trabecular meshwork cells and the anterior portion of sclera. These findings suggest that myocilin mutation could affect the capacity of aqueous outflow and cause elevation of the intraocular pressure which is involved in the pathogenesis of glaucoma.

本文言語English
ページ(範囲)104-109
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
248
1
DOI
出版ステータスPublished - 1998 7月 9

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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