Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia

Tetsuya Tagami, Hironori Kimura, Sumire Ohtani, Tsuyoshi Tanaka, Takashi Tanaka, Shiro Hata, Miho Saito, Yasushi Miyazaki, Rika Araki, Masami Tanaka, Kazuya Yonezawa, Morio Sawamura, Takuyuki Ise, Atsushi Ogo, Takuro Shimbo, Akira Shimatsu, Mitsuhide Naruse

研究成果: Article

19 引用 (Scopus)

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Hypercholesterolemia is one of the most representative disorders of the common diseases. To evaluate the prevalence of hypothyroidism in the population of adult hypercholesterolemia, we prospectively examined the thyroid function in patients with untreated or treated hypercholesterolemia as a multi-center survey. Subjects were the patients who were treated with some antilipemic agents or the untreated patients whose total cholesterol (TC) was over 220 mg/dL and/or LDL-cholesterol (LDL-C) over 140 mg/dL. Among 737 cases recruited, 725 cases (300 males and 425 females) participated in the survey including the thyroid function test. The patient's backgrounds include hypertension (51%), diabetes mellitus (49%), fatty liver (17%), smoking (15%), and habitual drinking (10%). The 72% of the patients were treated with some antilipemic agents and the mean values of TC, LDL-C, triglyceride (TG), HDL-cholesterol (HDL-C), and LDL-C/HDL-C ratio were 204.5 mg/dL, 119.6 mg/dL, 144.4 mg/dL, 60.7 mg/dL and 2.25, respectively. The primary hypothyroidism was seen in 27 cases (3.7%) (11 males, 16 females) with subclinical hypothyroidism in 17 cases (2.4%) and overt hypothyroidism in 10 cases (1.4%). The central hypothyroidism was seen in 4 cases (0.6%). The prevalence of hypothyroidism was 4.3% in patients with hypercholesterolemia. Taking account of the large number of patients with dyslipidemia and importance of avoiding unnecessary administration and associated adverse effects, evaluation of the thyroid function could be warranted in patients with dyslipidemia although cost-benefit issues waits further investigation.

元の言語English
ページ(範囲)449-457
ページ数9
ジャーナルEndocrine journal
58
発行部数6
DOI
出版物ステータスPublished - 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Tagami, T., Kimura, H., Ohtani, S., Tanaka, T., Tanaka, T., Hata, S., Saito, M., Miyazaki, Y., Araki, R., Tanaka, M., Yonezawa, K., Sawamura, M., Ise, T., Ogo, A., Shimbo, T., Shimatsu, A., & Naruse, M. (2011). Multi-center study on the prevalence of hypothyroidism in patients with hypercholesterolemia. Endocrine journal, 58(6), 449-457. https://doi.org/10.1507/endocrj.K11E-012