Multi-omics data-driven systems biology of E. coli

Nobuyoshi Ishii, Masaru Tomita

研究成果: Chapter

17 被引用数 (Scopus)

抄録

The omics, which means comprehensive analysis of a specific layer in a cellular system, are emerging as essential methodological approaches for molecular biology and systems biology. However, single omics analysis does not always provide enough information to understand the behaviors of a cellular system. Therefore, a combination of multiple omics analyses, the multi-omics approach, is required to acquire a precise picture of living organisms. In this chapter, basic concepts of omics studies, and recent technologies in the omics of metabolism and published multi-omics analyses of Escherichia coli, are reviewed. Subsequently, a large-scale multi-omics analysis of E. coli K-12, including transcriptomics, proteomics, metabolomics and fluxomics, is presented. This study uncovered the complementary strategies of E. coli that result in a metabolic network robust against various types of perturbations, therefore demonstrating the power of a multi-omics, data-driven approach for understanding the functional principles of total cellular systems.

本文言語English
ホスト出版物のタイトルSystems Biology and Biotechnology of Escherichia coli
出版社Springer Netherlands
ページ41-57
ページ数17
ISBN(印刷版)9781402093937
DOI
出版ステータスPublished - 2009 12 1

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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