Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern

M. Sakamoto, S. Hirohashi, H. Tsuda, Y. Shimosato, M. Makuuchi, Y. Hosoda

研究成果: Article査読

109 被引用数 (Scopus)

抄録

Two separate nodular lesions of hepatocellular carcinoma (HCC) were surgically removed from a patient with positive serum hepatitis B surface antigen. Southern blot analysis of DNA from the two separate HCC lesions showed different restriction patterns of integrated hepatitis B virus DNA, indicating their independent origins. The two lesions were composed mainly of poorly differentiated HCC; however, well-differentiated HCC was also observed in the periphery of the lesions. This histological findings is consistent with the multistep and independent development of HCC in each site of the liver.

本文言語English
ページ(範囲)1064-1067
ページ数4
ジャーナルAmerican Journal of Surgical Pathology
13
12
DOI
出版ステータスPublished - 1989
外部発表はい

ASJC Scopus subject areas

  • 解剖学
  • 外科
  • 病理学および法医学

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