Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics

Binbin Tan, Atsushi Matsuda, Yan Zhang, Atsushi Kuno, Hisashi Narimatsu

研究成果: Article査読

7 被引用数 (Scopus)

抄録

To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.

本文言語English
ページ(範囲)201-205
ページ数5
ジャーナルMolecular BioSystems
10
2
DOI
出版ステータスPublished - 2014 2 1
外部発表はい

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分子生物学

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