Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics

Binbin Tan, Atsushi Matsuda, Yan Zhang, Atsushi Kuno, Hisashi Narimatsu

研究成果: Article

6 引用 (Scopus)

抜粋

To survey the glycome shift in cancer, single-dot tissue glycome profiling was improved by incorporating a lectin-assisted fractionation. The differential analysis of tissue specimens from colorectal cancer patients (n = 45) revealed that unfucosylated/α2,6-sialylated glycoproteins significantly increased in patients with poor prognoses. The detailed annotation will be an indispensable supplement for cancer-related glyco-biomarker discovery.

元の言語English
ページ(範囲)201-205
ページ数5
ジャーナルMolecular BioSystems
10
発行部数2
DOI
出版物ステータスPublished - 2014 2 1
外部発表Yes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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