A case of multiple cerebral aneurysms associated with neurofibromatosis is reported. In April, 1995, a 64-year-old woman, who had been clinically diagnosed as having neurofibromatosis about 20 years previously, underwent check-up screening of cerebral diseases, and multiple cerebral aneurysms were found incidentally by MR angiography. Angiography performed in our hospital revealed 2 unruptured aneurysms; a saccular aneurysm of the right middle cerebral artery (MCA), a local but non aneurysmal dilatation of the right internal carotid artery, and a giant fusiform aneurysm of the basilar artery. The patient was operated on with clipping and wrapping of the right MCA aneurysm and discharged without neurological deficits. The biopsy specimen of the right superficial temporal artery (STA) revealed fibrous thickening of the intima and partial fragmentation of the internal elastic laminae. With analysis of 18 cases in previous reports, those pathological changes on the vessels might be related with the formation of cerebral aneurysms.
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