Multiple deletions in mitochondrial DNA at direct repeats of non-D-loop regions in cases of familial mitochondrial myopathy

Michisuke Yuzaki, Norio Ohkoshi, Ichiro Kanazawa, Yasuo Kagawa, Shigeo Ohta

研究成果: Article査読

71 被引用数 (Scopus)

抄録

Muscle mitochondrial DNAs from two brothers with mitochondrial myopathy associated with peripheral neuropathy had multiple deletions, most of which started in non-D-loop regions, unlike in an autosomal dominant mitochondrial myopathy (Zeviani, M. et al., Nature 339, 309 (1989)). The non-D-loop regions with deletions were amplified by the polymerase chain reaction and the resulting fragments were subcloned and then sequenced. At least 12 deletions of different lengths in different sites were found. However, all the deletions were flanked by short direct repeats (4-12 base pairs).

本文言語English
ページ(範囲)1352-1357
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
164
3
DOI
出版ステータスPublished - 1989 11 15
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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