Multiple Scedosporium apiospermum abscesses in a woman survivor of a tsunami in northeastern Japan: A case report

Yutaka Nakamura, Yu Utsumi, Naomi Suzuki, Yoshio Nakajima, Okinori Murata, Nobuhito Sasaki, Hiroo Nitanai, Hiromi Nagashima, Shinya Miyamoto, Jun Yaegashi, Tomoki Hatakeyama, Yoshihiro Shibano, Kyoko Yarita, Katsuhiko Kamei, Toshihide Nakadate, Shigeatsu Endo, Yasuo Terayama, Kohei Yamauchi

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Introduction. Scedosporium apiospermum is increasingly recognized as a cause of localized and disseminated mycotic infections in near-drowning victims. Case presentation. We report the case of a 59-year-old Japanese woman who was a survivor of a tsunami in northeastern Japan and who had lung and brain abscesses caused by S. apiospermum. Initially, an aspergillus infection was suspected, so she was treated with micafungin. However, computed tomography scans of her chest revealed lung abscesses, and magnetic resonance images demonstrated multiple abscesses in her brain. S. apiospermum was cultured from her bronchoalveolar lavage fluid, and antimycotic therapy with voriconazole was initiated. Since she developed an increase in the frequency of premature ventricular contractions, an adverse drug reaction to the voriconazole was suspected. She was started on a treatment of a combination of low-dose voriconazole and liposomal amphotericin B. After combination therapy, further computed tomography scans of the chest and magnetic resonance images of her brain showed a demarcation of abscesses. Conclusions: Voriconazole appeared to have a successful record in treating scedosporiosis after a near drowning but, owing to several adverse effects, may possibly not be recommended. Thus, a combination treatment of low-dose voriconazole and liposomal amphotericin B may be a safe and effective treatment for an S. apiospermum infection. Even though a diagnosis of scedosporiosis may be difficult, a fast and correct etiological diagnosis could improve the patient's chance of recovery in any case.

本文言語English
論文番号526
ジャーナルJournal of Medical Case Reports
5
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • Medicine(all)

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