Multivalent Effect in Influenza Hemagglutinin-Binding Activity of Sugar-Mimic Peptide

Teruhiko Matsubara, Ai Onishi, Tomomi Saito, Daisuke Yamaguchi, Toshinori Sato

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Hemagglutinin (HA) of the influenza virus binds to sialyloligosaccaride receptors on the cell surface in the first step of infection; therefore, inhibitors of the HA-receptor interaction have potential as anti-influenza drugs. We previously identified the HA-binding peptide s2, ARLPRTMVHPKPAQP, from random peptide libraries using phage-display technology. The N-stearoyl s2 peptide showed inhibitory activity against influenza virus infection. To obtain molecules with high affinity for HAs, truncated s2 peptides and dendrimers were designed in the present study. The affinity of dendrimers functionalized with the truncated peptide was higher than that of the full-length s2 peptide, especially a tetrameric dendrimer with ARLPR was more than 70-times more effective than the s2 peptide.

本文言語English
ページ(範囲)62-68
ページ数7
ジャーナルKobunshi Ronbunshu
73
1
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • ポリマーおよびプラスチック
  • 環境科学(全般)
  • 材料科学(その他)
  • 化学工学(その他)

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