Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization

Hiroyuki Yoshida, Aya Nagaoka, Sachiko Nakamura, Yoshinori Sugiyama, Yasunori Okada, Shintaro Inoue

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Recently, we have disclosed that human KIAA1199 (hKIAA1199) is a hyaluronan (HA) binding protein implicated in HA depolymerization. Although a murine homologue (mKiaa1199) was previously cloned, no information about the function of the molecule was available. Here, we show that cells transfected with mKiaa1199 cDNA selectively catabolized HA via the clathrin-coated pit pathway. A glycosaminoglycan-binding assay demonstrated the specific binding of mKiaa1199 to HA. These results were similar to our observations with hKIAA1199, although slight differences were found in the peak sizes of the minimum degradates of HA. We conclude that like hKIAA1199, mKiaa1199 is a hyaladherin, leading to HA depolymerization.

本文言語English
ページ(範囲)352-356
ページ数5
ジャーナルFEBS Open Bio
3
DOI
出版ステータスPublished - 2013 8月

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル