TY - JOUR
T1 - Musashi, a neural RNA-binding protein required for drosophila adult external sensory organ development
AU - Nakamura, Makoto
AU - Okano, Hideyuki
AU - Blendy, Julie A.
AU - Montell, Craig
N1 - Funding Information:
The first two authors contributed equally to this work. We thank A. S. Spradling and members of his laboratory for providing the P element insertion lines, A. C. Bang and J. W. Posakony for demonstrating the dissections of the pupal notum, and K. Kimura for advice on notum staining. We also thank H. Bellen for the Al01 enhancer trap line and N. Pate1 for MAb44Cll and MAb22ClO. M. N. was a recipient of an International Human Frontier Science Program Organization Long Term Fellowship, and J. A. B. was supported by a National Institutes of Health postdoctoral fellowship. This work was supported by a grant from the American Cancer Society (NP-798) to C. M. In addition, C. M. acknowledges support from a National Science Foundation Presidential Young Investigator Award and an American Cancer Society Junior Faculty Research Award.
PY - 1994/7
Y1 - 1994/7
N2 - A family of neural RNA-binding proteins has recently been described in both vertebrates and invertebrates. We have identified a new member of this family, the Drosophila musashi (msi) locus, which is required for development of adult external sensory organs (sensilla). In contrast with wild-type sensilla, which contain two outer support cells, the msi mutation typically results in the appearance of extra outer support cells. The msi putative RNA-binding protein is localized to the nucleus and appears to be expressed in all cells in each sensillum and predominantly in neurons during embryogenesis. We propose that the msi protein regulates sensillum development by controlling the expression of target genes at the posttranscriptional level.
AB - A family of neural RNA-binding proteins has recently been described in both vertebrates and invertebrates. We have identified a new member of this family, the Drosophila musashi (msi) locus, which is required for development of adult external sensory organs (sensilla). In contrast with wild-type sensilla, which contain two outer support cells, the msi mutation typically results in the appearance of extra outer support cells. The msi putative RNA-binding protein is localized to the nucleus and appears to be expressed in all cells in each sensillum and predominantly in neurons during embryogenesis. We propose that the msi protein regulates sensillum development by controlling the expression of target genes at the posttranscriptional level.
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U2 - 10.1016/0896-6273(94)90460-X
DO - 10.1016/0896-6273(94)90460-X
M3 - Article
C2 - 8043282
AN - SCOPUS:0028111671
SN - 0896-6273
VL - 13
SP - 67
EP - 81
JO - Neuron
JF - Neuron
IS - 1
ER -