Musashi: A translational regulator of cell fate

Hideyuki Okano, Takao Imai, Masataka Okabe

研究成果: Article査読

284 被引用数 (Scopus)

抄録

Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.

本文言語English
ページ(範囲)1355-1359
ページ数5
ジャーナルJournal of Cell Science
115
7
出版ステータスPublished - 2002 4月 1

ASJC Scopus subject areas

  • 細胞生物学

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