Musashi and Seven in absentia downregulate Tramtrack through distinct mechanisms in Drosophila eye development

Yuki Hirota, Masataka Okabe, Takao Imai, Mitsuhiko Kurusu, Atsuyo Yamamoto, Sachiyo Miyao, Makoto Nakamura, Kazunobu Sawamoto, Hideyuki Okano

研究成果: Article

32 引用 (Scopus)

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We have examined the roles played by the Drosophila neural RNA-binding protein Musashi (MSI) in eye development. MSI expression was observed in the nuclei of all photoreceptor cells (R1-R8). Although a msi loss-of-function mutation resulted in only weak abnormalities in photoreceptor differentiation, we found that the msi eye phenotype was significantly enhanced in a seven in absentia (sina) background. sina is known to be involved in the degradation of the Tramtrack (TTK) protein, leading to the specification of the R7 fate. We demonstrated that MSI also functions to regulate TTK expression. The sina msi mutants showed significantly high ectopic expression of TTK69 and failure in the determination of the R1, R6, and R7 fates. Other photoreceptor cells also failed to differentiate with abnormalities occurring late in the differentiation process. These results suggest that MSI and SINA function redundantly to downregulate TTK in developing photoreceptor cells. Copyright (C) 1999 Elsevier Science Ireland Ltd.

元の言語English
ページ(範囲)93-101
ページ数9
ジャーナルMechanisms of Development
87
発行部数1-2
DOI
出版物ステータスPublished - 1999 9 1

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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