Muscle fibers actuated by neural signals

Y. Morimoto, M. Kato-Negishi, H. Onoe, S. Takeuchi

研究成果: Conference contribution

抄録

We propose a method for constructing "neuron-muscle fibers" driven by signals from activated neurons. The fibers consist of stretched muscle fibers covered with highly aligned neurons, and the axons of neurons extend into muscle fibers and form neuromuscular junctions (NMJs). We successfully constructed the neuron-muscle fibers by culturing neural stem cells on stretched muscle fibers; the neural stem cells then differentiated into neurons and connected to muscle cells, forming NMJs. Furthermore, we found that the neuron-muscle fibers contract after treatment of glutamic acid that activates neurons to stimulate the muscle cells. We believe that our neuron-muscle fibers will be not only used as soft-robotic actuators controlled by neuronal signals, but also used in therapeutic and pharmacokinetic assays for NMJ disease models.

本文言語English
ホスト出版物のタイトル2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
ページ866-869
ページ数4
DOI
出版ステータスPublished - 2012 5 7
外部発表はい
イベント2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
継続期間: 2012 1 292012 2 2

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN(印刷版)1084-6999

Other

Other2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
CountryFrance
CityParis
Period12/1/2912/2/2

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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