Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis

Tomonori Kaneda, Yoshiko Sonoda, Kumi Ando, Takaharu Suzuki, Yasuhiro Sasaki, Tomoyuki Oshio, Megumi Tago, Tadashi Kasahara

研究成果: Article査読

43 被引用数 (Scopus)

抄録

This study focused on the role of focal adhesion kinase (FAK), a cytoplasmic tyrosine kinase important for many cellular processes, in the proliferation, adhesion, and invasion of melanoma cells in vitro and in vivo. We found that the Y925F-mutation of FAK in B16F10 melanoma cells suppressed metastasis in an experimental model, which correlated well with decreased extracellular matrix dependent proliferative capability, adhesive, migrational, and invasive capabilities. Transduction of the mutation Y925F resulted in a down-regulation of the phosphorylation of Erk, the expression of VEGF, and the association of FAK with paxillin. The results provide clear evidence that 925Y of FAK is critical for melanoma metastasis and this phosphorylation site will be an anti-metastatic target.

本文言語English
ページ(範囲)354-361
ページ数8
ジャーナルCancer Letters
270
2
DOI
出版ステータスPublished - 2008 11 8

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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