Mutational analysis of β-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours

Masashi Mikami, Katsuhiko Nosho, Hiroyuki Yamamoto, Taiga Takahashi, Tadateru Maehata, Hiroaki Taniguchi, Yasushi Adachi, Akimichi Imamura, Masahiro Fujita, Masao Hosokawa, Fumio Itoh, Kohzoh Imai, Yasuhisa Shinomura

研究成果: Article

18 引用 (Scopus)

抜粋

Morphologically, early colorectal tumours can be divided into two groups, protruded-type and flat-type. However, little is known about genetic mechanisms of the latter. We investigated mutations of β-catenin, KRAS, BRAF, and PIK3CA in 310 early colorectal tumours. β-catenin mutation was detected in 7.1% of 310 tumours. β-catenin mutation was detected in a significantly higher percentage of flat-type tumours with depressed areas (4/17, 23.5%) than in other tumours (18/293, 6.1%; p = 0.0246). KRAS, BRAF, and PIK3CA mutations were detected in 21.6%, 5.4%, and 1.0% of 310 tumours, respectively. Concomitant mutations of β-catenin and KRAS or BRAF were detected in seven tumours. Mutation of at least one gene was detected in a significantly higher percentage of flat-type tumour tissues (75/193, 38.9%) than in protruded-type tumour tissues (25/117, 21.4%; p = 0.0014), and it was correlated significantly with size (p = 0.0001). In conclusion, β-catenin mutation seemed to play an important role in flat-type tumours, especially in those with depressed areas. The genetic abnormalities could arise and accumulate in the early stage of colorectal tumourigenesis, and seem to contribute to the development of flat-type tumour.

元の言語English
ページ(範囲)3065-3072
ページ数8
ジャーナルEuropean Journal of Cancer
42
発行部数17
DOI
出版物ステータスPublished - 2006 11 1
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Mutational analysis of β-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Mikami, M., Nosho, K., Yamamoto, H., Takahashi, T., Maehata, T., Taniguchi, H., Adachi, Y., Imamura, A., Fujita, M., Hosokawa, M., Itoh, F., Imai, K., & Shinomura, Y. (2006). Mutational analysis of β-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours. European Journal of Cancer, 42(17), 3065-3072. https://doi.org/10.1016/j.ejca.2006.06.029