Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines

S. Simizu, H. Osada

研究成果: Article査読

116 被引用数 (Scopus)

抄録

It has been established that mutations in Drosophila Polo cause abnormalities in mitosis. In human cells, maximal Plk activity is reached in the M phase of the cell cycle, and the function of Plk is therefore considered to be required for mitotic cellular events such as spindle formation, chromosome segregation and cytokinesis. Microinjection of anti-Plk antibody into living cells has been found to induce a mitotic abnormality that contributes to the generation of aneuploidy, and this is an important finding in relation to tumour development. Indeed, previous studies have shown that the level of expression of a mitotic checkpoint gene, hsMAD2, is reduced and that another checkpoint gene, BUB1, is mutated in certain human cancer cells.

本文言語English
ページ(範囲)852-854
ページ数3
ジャーナルNature Cell Biology
2
11
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • 細胞生物学

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