Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration

Kazuo Kishi, Kyoji Ohyama, Hiroko Satoh, Yoshiaki Kubota, Takara Tanaka, Nobuaki Imanishi, Hideo Nakajima, Kohki Kawamura, Tatsuo Nakajima

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Mammalian fetal cutaneous wounds made at certain developmental stages show complete regeneration. It is reported that wound healing in both adult and fetal skin is disrupted by denervation. Furthermore, fetal cutaneous regeneration has unique aspects such as epidermal wrinkle texture regeneration and dermal regeneration that depend on developmental stage. Therefore, we have examined the relationship of fetal cutaneous regeneration with denervation. We made cutaneous wounds on fetal mice at various developmental time points including embryonic days (E)13, E15, and E17, and compared the regenerating patterns of peripheral nerves in the skin. We found that when the fetuses are wounded at an early stage of development, peripheral nerves regenerate quicker than at later stages of development when peripheral nerve regeneration is delayed. Next, we denervated the intercostal nerves and made wounds at the denervated sites on E13 and E15. We found that epidermal wrinkling and dermal regeneration were disrupted by denervation. These findings indicate that components of fetal cutaneous regeneration and peripheral nerve regeneration are mutually dependent.

本文言語English
ページ(範囲)91-99
ページ数9
ジャーナルWound Repair and Regeneration
14
1
DOI
出版ステータスPublished - 2006 1 1

ASJC Scopus subject areas

  • Surgery
  • Dermatology

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