Myocilin expression in the astrocytes of the optic nerve head

Setsuko Noda, Yukihiko Mashima, Minoru Obazawa, Ryo Kubota, Yoshihisa Oguchi, Jun Kudoh, Shinsei Minoshima, Nobuyoshi Shimizu

研究成果: Article査読

27 被引用数 (Scopus)

抄録

We investigated the expression of myocilin in the optic nerve head of porcine eyes by Western blotting and immunohistochemical staining. Myocilin was localized in the nucleus, centrosome, glial filament, mitochondria, and some parts of the cell membranes of the astrocytes. Myocilin was also detected at the edge-feet portion of the processes of astrocytes adjacent to the inner limiting membrane and blood vessel wall. The astrocytes are the major cell population in the optic nerve head, contributing to the architecture of the nerve axon and blood vessels. Therefore, myocilin gene mutation and change of myocilin protein are likely to affect the architecture of the optic nerve head and induce various forms of glaucomatous optic nerve damage. (C) 2000 Academic Press.

本文言語English
ページ(範囲)1129-1135
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
276
3
DOI
出版ステータスPublished - 2000 10 5

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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