Myoinositol to total choline ratio in glioblastomas as a potential prognostic factor in preoperative magnetic resonance spectroscopy

Masanobu Kumon, Shunsuke Nakae, Kazuhiro Murayama, Takema Kato, Shigeo Ohba, Joji Inamasu, Seiji Yamada, Masato Abe, Hikaru Sasaki, Yoshiharu Ohno, Mitsuhiro Hasegawa, Hiroki Kurahashi, Yuichi Hirose

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.

本文言語English
ページ(範囲)453-460
ページ数8
ジャーナルNeurologia medico-chirurgica
61
8
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • 外科
  • 臨床神経学

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