Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.

Shigeaki Suzuki, Yukiko K. Hayashi, Masataka Kuwana, Rie Tsuburaya, Norihiro Suzuki, Ichizo Nishino

研究成果: Article査読

70 被引用数 (Scopus)

抄録

To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy. Case series. Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.

本文言語English
ページ(範囲)728-732
ページ数5
ジャーナルArchives of neurology
69
6
出版ステータスPublished - 2012 6月

ASJC Scopus subject areas

  • 人文科学(その他)
  • 臨床神経学

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