N(α)-cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt, as an inactivator of hepatitis B surface antigen

Y. Sugimoto, S. Toyoshima

研究成果: Article査読

4 被引用数 (Scopus)

抄録

N(α)-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt (CAE), exhibited a strong inactivating effect on hepatitis B surface antigen. Concentrations of CAE required for 50 and 100% inactivation of the antigen were 0.01 to 0.025% and 0.025 to 0.05%, respectively. CAE completely inactivated hepatitis B surface antigen at the lowest concentration compared with various compounds including about 500 amino acid derivatives, sodium hypochlorite, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, and some detergents. Furthermore, CAE inactivated vaccinia virus, herpes simplex virus, and influenza virus, whereas poliovirus was not inactivated at all. The results suggest that the inactivating effects of CAE are related to interaction with lipid-containing viral envelopes.

本文言語English
ページ(範囲)329-332
ページ数4
ジャーナルAntimicrobial Agents and Chemotherapy
16
3
DOI
出版ステータスPublished - 1979

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)
  • 感染症

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