Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution

Shu Taira, Yuki Sugiura, Shinji Moritake, Shuichi Shimma, Yuko Ichiyanagi, Mitsutoshi Setou

研究成果: Article査読

116 被引用数 (Scopus)

抄録

Today, two-dimensional mass spectrometry analysis of biological tissues by means of a technique called mass imaging, mass spectrometry imaging (MSI), or imaging mass spectrometry (IMS) has found application in investigating the distribution of molecules - MSI with matrix-assisted laser desorption/ionization (MALDI) and secondary ion MS (SIMS). However, the size of the matrix crystal and the migration of analytes can decrease the spatial resolution in MALDI, and SIMS can only ionize compounds with relatively low molecular weights. To overcome these problems, we developed a nanoparticle-assisted laser desorption/ionization (nano-PALDI)-based MSI. We used nano-PALDI MSI to visualize lipids and peptides at a resolution of 15 μm in mammalian tissues.

本文言語English
ページ(範囲)4761-4766
ページ数6
ジャーナルAnalytical chemistry
80
12
DOI
出版ステータスPublished - 2008 6 15
外部発表はい

ASJC Scopus subject areas

  • Analytical Chemistry

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