Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection

Shigeo Koyasu, Kazuyo Moro, Masanobu Tanabe, Tsutomu Takeuchi

研究成果: Chapter

37 引用 (Scopus)

抜粋

The Th2-type immune response, characterized by the production of IL-4, IL-5, and IL-13, is a critical immune response against helminths invading cutaneous or mucosal sites. Th2 cytokines are induced soon after helminth infection, even before a pathogen-specific adaptive immune response is established. Although the expulsion and clearance of helminths usually requires pathogen-specific Th2-mediated immunity, early induction of Th2 cytokines during the innate immune phase is important for host protection from helminth invasion. Recent studies have shed light on such Th2 cytokine production by formerly uncharacterized innate immune cells such as a newly identified natural helper cell. We discuss here the mechanisms of innate production of Th2 cytokines in host immune responses against helminth infection.

元の言語English
ホスト出版物のタイトルAdvances in Immunology
出版者Academic Press Inc.
ページ21-44
ページ数24
エディションC
DOI
出版物ステータスPublished - 2010

出版物シリーズ

名前Advances in Immunology
番号C
108
ISSN(印刷物)0065-2776
ISSN(電子版)1557-8445

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • これを引用

    Koyasu, S., Moro, K., Tanabe, M., & Takeuchi, T. (2010). Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection. : Advances in Immunology (C 版, pp. 21-44). (Advances in Immunology; 巻数 108, 番号 C). Academic Press Inc.. https://doi.org/10.1016/B978-0-12-380995-7.00002-1