Naturally Occurring Polysaccharide Derivatives Which Behave as an Artificial Cell Wall on an Artificial Cell Liposome

Junzo Sunamoto, Toshinori Sato, Takayuki Taguchi, Hiroshi Hamazaki

研究成果: Article査読

69 被引用数 (Scopus)

抄録

In order to make a liposome more mechanically stable, the liposomal surface was coated with a naturally occurring polysaccharide which bears a hydrophobic anchor such as a cholesterol or palmitoyl residue. The effect of a hydrophobic anchor on the coating efficiency of the liposomal membrane was studied from the viewpoints of the permeability of a polysaccharide-coated liposome and the membrane fluidity. Through these investigations, it was found that coating of the liposomal surface with cholesterol derivatives of the polysaccharides was much better at decreasing the membrane permeability of a water-soluble fluorescent probe (6-carboxyfluorescein) than coating with O-palmitoylpolysaccharide.

本文言語English
ページ(範囲)5665-5670
ページ数6
ジャーナルMacromolecules
25
21
DOI
出版ステータスPublished - 1992 10月 1
外部発表はい

ASJC Scopus subject areas

  • 有機化学
  • ポリマーおよびプラスチック
  • 無機化学
  • 材料化学

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