Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada

研究成果: Review article査読

121 被引用数 (Scopus)

抄録

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.

本文言語English
ページ(範囲)100-110
ページ数11
ジャーナルArthritis Research and Therapy
7
3
DOI
出版ステータスPublished - 2005 6
外部発表はい

ASJC Scopus subject areas

  • リウマチ学
  • 免疫アレルギー学
  • 免疫学

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