Negative regulation of cytokine signaling and inflammatory diseases

Kyoko Inagaki-Ohara, Toshikatsu Hanada, Akihiko Yoshimura

研究成果: Review article査読

31 被引用数 (Scopus)

抄録

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activators of transcription (STATs). The cytokine-inducible SH2 proteins (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory system. Several recent advances have been made in this field, including treatment of inflammatory diseases by modulating extracellular and intracellular signaling pathways.

本文言語English
ページ(範囲)435-442
ページ数8
ジャーナルCurrent Opinion in Pharmacology
3
4
DOI
出版ステータスPublished - 2003 8 1
外部発表はい

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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