Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases.

T. Hanada, I. Kinjyo, K. Inagaki-Ohara, Akihiko Yoshimura

研究成果: Article

31 引用 (Scopus)

抄録

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

元の言語English
ページ(範囲)72-86
ページ数15
ジャーナルReviews of physiology, biochemistry and pharmacology
149
出版物ステータスPublished - 2003
外部発表Yes

Fingerprint

Suppressor of Cytokine Signaling Proteins
Cytokines
Proteins
STAT Transcription Factors
Janus Kinases
Interleukins
Protein-Tyrosine Kinases
Interferons
Immune System

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Pharmacology

これを引用

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