抄録
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 72-86 |
| ページ数 | 15 |
| ジャーナル | Reviews of physiology, biochemistry and pharmacology |
| 巻 | 149 |
| 出版物ステータス | Published - 2003 |
| 外部発表 | Yes |
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ASJC Scopus subject areas
- Physiology
- Biochemistry
- Pharmacology
これを引用
Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases. / Hanada, T.; Kinjyo, I.; Inagaki-Ohara, K.; Yoshimura, Akihiko.
：: Reviews of physiology, biochemistry and pharmacology, 巻 149, 2003, p. 72-86.研究成果: Article
}
TY - JOUR
T1 - Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases.
AU - Hanada, T.
AU - Kinjyo, I.
AU - Inagaki-Ohara, K.
AU - Yoshimura, Akihiko
PY - 2003
Y1 - 2003
N2 - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.
AB - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.
UR - http://www.scopus.com/inward/record.url?scp=1542493212&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1542493212&partnerID=8YFLogxK
M3 - Article
C2 - 12687406
AN - SCOPUS:1542493212
VL - 149
SP - 72
EP - 86
JO - Reviews of Physiology Biochemistry and Pharmacology
JF - Reviews of Physiology Biochemistry and Pharmacology
SN - 0303-4240
ER -