Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases.

T. Hanada, I. Kinjyo, K. Inagaki-Ohara, A. Yoshimura

研究成果: Review article査読

37 被引用数 (Scopus)

抄録

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

本文言語English
ページ(範囲)72-86
ページ数15
ジャーナルReviews of physiology, biochemistry and pharmacology
149
出版ステータスPublished - 2003
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 生理学
  • 薬理学
  • 生理学(医学)

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