Neoadjuvant chemotherapy and hyperfractionated radiation therapy for the urinary bladder carcinoma

R. Ishibashi, N. Shigematsu, T. Kawada, H. Ito, T. Nakayama, Y. Andou, A. Kubo, M. Tachibana

研究成果: Article

抜粋

The standard treatment for an invasive bladder cancer is radical surgery; however, the quality of life of the patients who undergo total cystectomy is unfavorable even when the ileal conduits were constructed. We carried out a bladder-conserving treatment for 8 bladder cancer patients by using a hyperfractionated radiotherapy together with low dose of cis-platinum or carboplatinum daily as a radiosensitizer following trans-urethral tumor resection and neoadjuvant chemotherapy. Cystoscopic findings and biopsies at one month after completing radiation showed complete remission (CR) and partial response (PR) for 5 and 3 patients, respectively. All of the PR cases had T4 tumors and the patients with tumors smaller than T3 and without lymph node metastasis achieved CR. All patients completed radiotherapy without acute severe complications. Six patients have remained alive for more than 10 months and radiation induced late complications such as bladder or intestinal insufficiency have not been observed thus far.

元の言語English
ページ(範囲)125-130
ページ数6
ジャーナルJournal of JASTRO
9
発行部数2
出版物ステータスPublished - 1997 1 1

    フィンガープリント

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

これを引用

Ishibashi, R., Shigematsu, N., Kawada, T., Ito, H., Nakayama, T., Andou, Y., Kubo, A., & Tachibana, M. (1997). Neoadjuvant chemotherapy and hyperfractionated radiation therapy for the urinary bladder carcinoma. Journal of JASTRO, 9(2), 125-130.