Nephroprotective effect of betamipron (BP) and its mechanism were investigated in view of renal transport of panipenem (PAPM), a new carbapenem antibiotic, in rabbits. Concomitant intravenous dose of BP (0.5～2 folds to PAPM) decreased dose-dependently the frequency of renal tubular necrosis caused by more than 150mg/kg of antibiotic administration. The decrement of nephrotoxicity was well correlated with the inhibitory activity of the renal cortical accumulation of PAPM. rhe optimal dose ratio of BP was equivalent to PAPM as weight. Such nephroprotective effect of BP was also observed in rabbits with acute glomerular nephritis. Both of BP and probenecid, an organic anion transport inhibitor, were practically prevented the〔14C〕 PAPM uptake in isolated renal tubule. BP hardly inhibited the rat renal dehydropeptidase- I activity unlike cilastatin. Nontoxic and nephroselective properties of BP might be full of promise to clinical use as a desirable nephroprotective agent for PAPM.
|出版ステータス||Published - 1991 1月 1|
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