Nerve growth factor treatment induces high-potassium-evoked calcium-dependent acetylcholine release in cultured embryonic rat septal cells

Takeshi Suzuki, Masaru Kanagawa, Yuko Takada, Kazuko Fujimoto, Koichiro Kawashima

研究成果: Article査読

12 被引用数 (Scopus)

抄録

The effects of dibutyryl cAMP (dbcAMP) and nerve growth factor (NGF) on acetylcholine (ACh) release from primary cultured cells of embryonic rat septum were studied. Both dbcAMP and NGF increased the activity of choline acetyltransferase and contents of intracellular and spontaneously released ACh without affecting the total protein content. High-potassium-evoked ACh release was observed in NGF-treated cells but not in untreated and dbcAMP-treated cells. These results indicate that NGF induces cholinergic maturation from induction of the ACh-synthetic enzyme to the excitation-secretion processes.

本文言語English
ページ(範囲)311-314
ページ数4
ジャーナルBrain Research
665
2
DOI
出版ステータスPublished - 1994 12 5

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

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