Neural ECM and synaptogenesis

Anne Heikkinen, Taina Pihlajaniemi, Andreas Faissner, Michisuke Yuzaki

研究成果: Chapter

27 被引用数 (Scopus)


Chemical synapses allow neurons to perform complex computations and regulate other systems of the body. At a chemical synapse, pre- and postsynaptic sites are separated by a small space (the synaptic cleft) and surrounded by astrocytes. The basement membrane (BM), a sheetlike, specialized extracellular matrix (ECM), is found ubiquitously in the PNS. It has become clear that the ECMs not only play a structural role but also serve as barriers and filters in the PNS and CNS. Moreover, proteoglycans and tenascin family proteins in the ECM regulate synapse formation and synaptic plasticity. Although CNS synapses lack the BMs, recent results indicate that the BM-associated collagens are also present in the CNS synaptic cleft and affect synaptogenesis in both the CNS and the PNS. The C1q domain-containing family proteins are important components of the CNS synaptic cleft in regulating synapse formation, maintenance, and the pruning process. The ECM is regarded as a crucial component of the tetrapartite synapse, consisting of pre- and postsynaptic neurons, astrocyte, and ECM.

ホスト出版物のタイトルProgress in Brain Research
出版者Elsevier B.V.
出版物ステータスPublished - 2014 1 1


名前Progress in Brain Research

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 「Neural ECM and synaptogenesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。