抄録
Background: Patients with major depressive disorder (MDD) perform poorly on the Stroop task, which is a measure of the executive control of attention, with impaired interference resolution. The neural correlates of this deficit are not well described. To examine how this deficit relates to pathophysiological abnormalities in MDD, we conducted an fMRI Stroop study comparing MDD subjects to controls. Methods: Forty-two unmedicated patients with current MDD and 17 control subjects underwent fMRI scanning with a color-word Stroop task. Subjects assessed font color during alternating color identification (e.g., 'XXXX in blue) and incongruent color/word blocks (e.g., the word 'red in blue). We examined neural activation that was greater in incongruent than color identification blocks (Z>2.3 and corrected p<0.05), controlling for trial-by-trial reaction time. Results: Compared to controls, MDD subjects exhibited lower activation during incongruent blocks across multiple brain regions, including middle frontal gyrus, paracingulate and posterior cingulate, precuneus, occipital regions, and brain stem. No brain regions were identified in which MDD subjects were more active than controls during incongruent blocks. Limitations: Not all MDD subjects were antidepressant-naïve. Conclusions: Brain regions related to executive function, visual processing, and semantic processing are less active during processing of incongruent stimuli in MDD subjects as compared to controls. Deficits of attention in MDD may be the product of a failure to maintain activity across a distributed network in a sustained manner, as is required over the sequential trials in this block design. Further studies may clarify whether the abnormalities represent a trait or state deficit.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 241-247 |
| ページ数 | 7 |
| ジャーナル | Journal of Affective Disorders |
| 巻 | 143 |
| 発行部数 | 1-3 |
| DOI | |
| 出版物ステータス | Published - 2012 12 20 |
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ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
これを引用
Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder. / Kikuchi, Toshiaki; Miller, Jeffrey M.; Schneck, Noam; Oquendo, Maria A.; John Mann, J.; Parsey, Ramin V.; Keilp, John G.
：: Journal of Affective Disorders, 巻 143, 番号 1-3, 20.12.2012, p. 241-247.研究成果: Article
}
TY - JOUR
T1 - Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder
AU - Kikuchi, Toshiaki
AU - Miller, Jeffrey M.
AU - Schneck, Noam
AU - Oquendo, Maria A.
AU - John Mann, J.
AU - Parsey, Ramin V.
AU - Keilp, John G.
PY - 2012/12/20
Y1 - 2012/12/20
N2 - Background: Patients with major depressive disorder (MDD) perform poorly on the Stroop task, which is a measure of the executive control of attention, with impaired interference resolution. The neural correlates of this deficit are not well described. To examine how this deficit relates to pathophysiological abnormalities in MDD, we conducted an fMRI Stroop study comparing MDD subjects to controls. Methods: Forty-two unmedicated patients with current MDD and 17 control subjects underwent fMRI scanning with a color-word Stroop task. Subjects assessed font color during alternating color identification (e.g., 'XXXX in blue) and incongruent color/word blocks (e.g., the word 'red in blue). We examined neural activation that was greater in incongruent than color identification blocks (Z>2.3 and corrected p<0.05), controlling for trial-by-trial reaction time. Results: Compared to controls, MDD subjects exhibited lower activation during incongruent blocks across multiple brain regions, including middle frontal gyrus, paracingulate and posterior cingulate, precuneus, occipital regions, and brain stem. No brain regions were identified in which MDD subjects were more active than controls during incongruent blocks. Limitations: Not all MDD subjects were antidepressant-naïve. Conclusions: Brain regions related to executive function, visual processing, and semantic processing are less active during processing of incongruent stimuli in MDD subjects as compared to controls. Deficits of attention in MDD may be the product of a failure to maintain activity across a distributed network in a sustained manner, as is required over the sequential trials in this block design. Further studies may clarify whether the abnormalities represent a trait or state deficit.
AB - Background: Patients with major depressive disorder (MDD) perform poorly on the Stroop task, which is a measure of the executive control of attention, with impaired interference resolution. The neural correlates of this deficit are not well described. To examine how this deficit relates to pathophysiological abnormalities in MDD, we conducted an fMRI Stroop study comparing MDD subjects to controls. Methods: Forty-two unmedicated patients with current MDD and 17 control subjects underwent fMRI scanning with a color-word Stroop task. Subjects assessed font color during alternating color identification (e.g., 'XXXX in blue) and incongruent color/word blocks (e.g., the word 'red in blue). We examined neural activation that was greater in incongruent than color identification blocks (Z>2.3 and corrected p<0.05), controlling for trial-by-trial reaction time. Results: Compared to controls, MDD subjects exhibited lower activation during incongruent blocks across multiple brain regions, including middle frontal gyrus, paracingulate and posterior cingulate, precuneus, occipital regions, and brain stem. No brain regions were identified in which MDD subjects were more active than controls during incongruent blocks. Limitations: Not all MDD subjects were antidepressant-naïve. Conclusions: Brain regions related to executive function, visual processing, and semantic processing are less active during processing of incongruent stimuli in MDD subjects as compared to controls. Deficits of attention in MDD may be the product of a failure to maintain activity across a distributed network in a sustained manner, as is required over the sequential trials in this block design. Further studies may clarify whether the abnormalities represent a trait or state deficit.
KW - Attention
KW - Depression
KW - Executive function
KW - Functional magnetic resonance imaging
KW - Incongruency
KW - Stroop task
UR - http://www.scopus.com/inward/record.url?scp=84869489320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869489320&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2012.05.016
DO - 10.1016/j.jad.2012.05.016
M3 - Article
C2 - 22995943
AN - SCOPUS:84869489320
VL - 143
SP - 241
EP - 247
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-3
ER -