Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder

Toshiaki Kikuchi, Jeffrey M. Miller, Noam Schneck, Maria A. Oquendo, J. John Mann, Ramin V. Parsey, John G. Keilp

研究成果: Article

17 引用 (Scopus)

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Background: Patients with major depressive disorder (MDD) perform poorly on the Stroop task, which is a measure of the executive control of attention, with impaired interference resolution. The neural correlates of this deficit are not well described. To examine how this deficit relates to pathophysiological abnormalities in MDD, we conducted an fMRI Stroop study comparing MDD subjects to controls. Methods: Forty-two unmedicated patients with current MDD and 17 control subjects underwent fMRI scanning with a color-word Stroop task. Subjects assessed font color during alternating color identification (e.g., 'XXXX in blue) and incongruent color/word blocks (e.g., the word 'red in blue). We examined neural activation that was greater in incongruent than color identification blocks (Z>2.3 and corrected p<0.05), controlling for trial-by-trial reaction time. Results: Compared to controls, MDD subjects exhibited lower activation during incongruent blocks across multiple brain regions, including middle frontal gyrus, paracingulate and posterior cingulate, precuneus, occipital regions, and brain stem. No brain regions were identified in which MDD subjects were more active than controls during incongruent blocks. Limitations: Not all MDD subjects were antidepressant-naïve. Conclusions: Brain regions related to executive function, visual processing, and semantic processing are less active during processing of incongruent stimuli in MDD subjects as compared to controls. Deficits of attention in MDD may be the product of a failure to maintain activity across a distributed network in a sustained manner, as is required over the sequential trials in this block design. Further studies may clarify whether the abnormalities represent a trait or state deficit.

元の言語English
ページ(範囲)241-247
ページ数7
ジャーナルJournal of Affective Disorders
143
発行部数1-3
DOI
出版物ステータスPublished - 2012 12 20

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Major Depressive Disorder
Magnetic Resonance Imaging
Color
Executive Function
Brain
Occipital Lobe
Parietal Lobe
Gyrus Cinguli
Semantics
Antidepressive Agents
Brain Stem
Reaction Time

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

これを引用

Kikuchi, T., Miller, J. M., Schneck, N., Oquendo, M. A., John Mann, J., Parsey, R. V., & Keilp, J. G. (2012). Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder. Journal of Affective Disorders, 143(1-3), 241-247. https://doi.org/10.1016/j.jad.2012.05.016

Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder. / Kikuchi, Toshiaki; Miller, Jeffrey M.; Schneck, Noam; Oquendo, Maria A.; John Mann, J.; Parsey, Ramin V.; Keilp, John G.

:: Journal of Affective Disorders, 巻 143, 番号 1-3, 20.12.2012, p. 241-247.

研究成果: Article

Kikuchi, T, Miller, JM, Schneck, N, Oquendo, MA, John Mann, J, Parsey, RV & Keilp, JG 2012, 'Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder', Journal of Affective Disorders, 巻. 143, 番号 1-3, pp. 241-247. https://doi.org/10.1016/j.jad.2012.05.016
Kikuchi, Toshiaki ; Miller, Jeffrey M. ; Schneck, Noam ; Oquendo, Maria A. ; John Mann, J. ; Parsey, Ramin V. ; Keilp, John G. / Neural responses to incongruency in a blocked-trial Stroop fMRI task in major depressive disorder. :: Journal of Affective Disorders. 2012 ; 巻 143, 番号 1-3. pp. 241-247.
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abstract = "Background: Patients with major depressive disorder (MDD) perform poorly on the Stroop task, which is a measure of the executive control of attention, with impaired interference resolution. The neural correlates of this deficit are not well described. To examine how this deficit relates to pathophysiological abnormalities in MDD, we conducted an fMRI Stroop study comparing MDD subjects to controls. Methods: Forty-two unmedicated patients with current MDD and 17 control subjects underwent fMRI scanning with a color-word Stroop task. Subjects assessed font color during alternating color identification (e.g., 'XXXX in blue) and incongruent color/word blocks (e.g., the word 'red in blue). We examined neural activation that was greater in incongruent than color identification blocks (Z>2.3 and corrected p<0.05), controlling for trial-by-trial reaction time. Results: Compared to controls, MDD subjects exhibited lower activation during incongruent blocks across multiple brain regions, including middle frontal gyrus, paracingulate and posterior cingulate, precuneus, occipital regions, and brain stem. No brain regions were identified in which MDD subjects were more active than controls during incongruent blocks. Limitations: Not all MDD subjects were antidepressant-na{\"i}ve. Conclusions: Brain regions related to executive function, visual processing, and semantic processing are less active during processing of incongruent stimuli in MDD subjects as compared to controls. Deficits of attention in MDD may be the product of a failure to maintain activity across a distributed network in a sustained manner, as is required over the sequential trials in this block design. Further studies may clarify whether the abnormalities represent a trait or state deficit.",
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KW - Incongruency

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