Neural stem cells, adult neurogenesis, and galectin-1: From bench to bedside

Masanori Sakaguchi, Hideyuki Okano

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Neural stem cells (NSCs) in the adult brain have been a consistent focus of biomedical research largely because of their potential clinical application. To fully exploit this potential, the molecular mechanisms that regulate NSCs must be clarified. Several lines of evidence show that a multifunctional protein, Galectin-1, is expressed and has a functional role in a subset of adult NSCs. Researchers, including our group, have explored the physiological role of Galectin-1 in NSCs and its application in the treatment of animal models of neurological disorders such as brain ischemia and spinal cord injury. Here, we summarize what is currently known regarding the role of Galectin-1 in adult NSCs. Furthermore, we discuss current issues in researching the role of Galectin-1 in adult NSCs under both physiological and pathological conditions.

本文言語English
ページ(範囲)1059-1067
ページ数9
ジャーナルDevelopmental Neurobiology
72
7
DOI
出版ステータスPublished - 2012 7

ASJC Scopus subject areas

  • 発達神経科学
  • 細胞および分子神経科学

フィンガープリント

「Neural stem cells, adult neurogenesis, and galectin-1: From bench to bedside」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル