Neural stem cells: The basic biology and prospects for brain repair

研究成果: Article

1 引用 (Scopus)

抄録

Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications to the damaged brain. By understanding of nature of NSCs present in CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localizations of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, which will be introduced in this review, it would be possible to develop a feasible strategy to manipulate cells in situ to treat the damaged brain.

元の言語English
ページ(範囲)1036-1040
ページ数5
ジャーナルClinical Neurology
41
発行部数12
出版物ステータスPublished - 2001 12 1

Fingerprint

Neural Stem Cells
Brain
Stem Cells
Developmental Biology
Oligodendroglia
Population Dynamics
Astrocytes
Signal Transduction
Maintenance
Phenotype
Neurons

ASJC Scopus subject areas

  • Clinical Neurology

これを引用

Neural stem cells : The basic biology and prospects for brain repair. / Okano, Hideyuki.

:: Clinical Neurology, 巻 41, 番号 12, 01.12.2001, p. 1036-1040.

研究成果: Article

@article{50dd331e88c547818dc56461093df7eb,
title = "Neural stem cells: The basic biology and prospects for brain repair",
abstract = "Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications to the damaged brain. By understanding of nature of NSCs present in CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localizations of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, which will be introduced in this review, it would be possible to develop a feasible strategy to manipulate cells in situ to treat the damaged brain.",
keywords = "Multipotency, Regional identity, Self-renewality, Transdifferentiation, Transplantation",
author = "Hideyuki Okano",
year = "2001",
month = "12",
day = "1",
language = "English",
volume = "41",
pages = "1036--1040",
journal = "Clinical Neurology",
issn = "0009-918X",
publisher = "Societas Neurologica Japonica",
number = "12",

}

TY - JOUR

T1 - Neural stem cells

T2 - The basic biology and prospects for brain repair

AU - Okano, Hideyuki

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications to the damaged brain. By understanding of nature of NSCs present in CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localizations of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, which will be introduced in this review, it would be possible to develop a feasible strategy to manipulate cells in situ to treat the damaged brain.

AB - Neural stem cells (NSCs) are multipotential progenitor cells that have self-renewal activities. A single NSC is capable of generating various kinds of cells within the CNS, including neurons, astrocytes, and oligodendrocytes. Because of these characteristics, there is an increasing interest in NSCs and neural progenitor cells from the aspects of both basic developmental biology and therapeutic applications to the damaged brain. By understanding of nature of NSCs present in CNS, extracellular factors and signal transduction cascades involved in the differentiation and maintenance of NSCs, population dynamics and localizations of NSCs in embryonic and adult brains, prospective identification and isolation of NSCs, and induction of NSCs into particular neuronal phenotypes, which will be introduced in this review, it would be possible to develop a feasible strategy to manipulate cells in situ to treat the damaged brain.

KW - Multipotency

KW - Regional identity

KW - Self-renewality

KW - Transdifferentiation

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=0035760918&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035760918&partnerID=8YFLogxK

M3 - Article

C2 - 12235790

AN - SCOPUS:0035760918

VL - 41

SP - 1036

EP - 1040

JO - Clinical Neurology

JF - Clinical Neurology

SN - 0009-918X

IS - 12

ER -