TY - JOUR
T1 - Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis
AU - Seki, M.
AU - Suzuki, Shigeaki
AU - Iizuka, T.
AU - Shimizu, Toshihiko
AU - Nihei, Yoshihiro
AU - Suzuki, Norihiro
AU - Dalmau, J.
PY - 2008/3
Y1 - 2008/3
N2 - We report an 18-year-old woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, who developed psychiatric symptoms, progressive unresponsiveness, dyskinesias, hypoventilation, hypersalivation and seizures. Early removal of an ovarian teratoma followed by plasma exchange and corticosteroids resulted in a prompt neurological response and eventual full recovery. Serial analysis of antibodies to NR1/NR2B heteromers of the NMDAR showed an early decrease of serum titres, although the cerebrospinal fluid titres correlated better with clinical outcome. The patients' antibodies reacted with areas of the tumour that contained NMDAR-expressing tissue. Search for and removal of a teratoma should be promptly considered after the diagnosis of anti-NMDAR encephalitis.
AB - We report an 18-year-old woman with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, who developed psychiatric symptoms, progressive unresponsiveness, dyskinesias, hypoventilation, hypersalivation and seizures. Early removal of an ovarian teratoma followed by plasma exchange and corticosteroids resulted in a prompt neurological response and eventual full recovery. Serial analysis of antibodies to NR1/NR2B heteromers of the NMDAR showed an early decrease of serum titres, although the cerebrospinal fluid titres correlated better with clinical outcome. The patients' antibodies reacted with areas of the tumour that contained NMDAR-expressing tissue. Search for and removal of a teratoma should be promptly considered after the diagnosis of anti-NMDAR encephalitis.
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U2 - 10.1136/jnnp.2007.136473
DO - 10.1136/jnnp.2007.136473
M3 - Article
C2 - 18032452
AN - SCOPUS:39749107975
SN - 0022-3050
VL - 79
SP - 324
EP - 326
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
IS - 3
ER -
