Neuronal migration in cortical development

Shigeaki Kanatani, Hidenori Tabata, Kazunori Nakajima

研究成果: Review article査読

25 被引用数 (Scopus)

抄録

Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more detailed understanding of the mitotic behavior of radial glia and the migrating behavior of their daughter cells. In this review, we describe recent progress in elucidating neuronal migration in brain formation and how neuronal migration is disturbed by mutations in genes that control this process.

本文言語English
ページ(範囲)274-279
ページ数6
ジャーナルJournal of Child Neurology
20
4
DOI
出版ステータスPublished - 2005 4月

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 臨床神経学

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