@article{3fde9229d0c9473193c750e8fc0344cb,
title = "Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation",
abstract = "Neuronal and immune systems coordinately orchestrate responses at mucosal barriers. Nagashima et al. applied scRNA-seq technology to track type 2 immune responses in worm infection, identifying neuropeptide CGRP as a factor that modulates inflammation. The study suggests that CGRP may be a useful target in type 2 inflammation.",
keywords = "CGRP, IL-33, NMU, Nippostrongylus brasiliensis, cytokines, host defense, immunoregulation, innate lymphoid cells, neuropeptides, single-cell RNA-seq",
author = "Hiroyuki Nagashima and Tanel Mahlak{\~o}iv and Shih, {Han Yu} and Davis, {Fred P.} and Francoise Meylan and Yuefeng Huang and Harrison, {Oliver J.} and Chen Yao and Yohei Mikami and Urban, {Joseph F.} and Caron, {Kathleen M.} and Yasmine Belkaid and Yuka Kanno and David Artis and O'Shea, {John J.}",
note = "Funding Information: We thank members of Molecular Immunology and Inflammation Branch (NIAMS) for input and support. We thank S. Dell{\textquoteright}Orso, G. Gutierrez-Cruz, and F. Naz (Genome Analysis Core Facility, NIAMS); J. Simone, J. Lay, and K. Tinsley (Flow Cytometry Section, NIAMS); H-W. Sun and S.R. Brooks (Biodata Mining and Discovery Section, NIAMS); E. Ralston and A. Kenea (Light Imaging Section, NIAMS); and L. Samsel and P. J. McCoy (Flow Cytometry Core, NHLBI) for their technical support. This study utilized the high-performance computational capabilities of the Biowulf Linux cluster at the NIH. This work was supported by the Intramural Research Programs of NIAMS and NIAID . Research in the Artis laboratory is supported by the National Institutes of Health ( AI074878 , AI095466 , AI095608 , and AI102942 ), the Burroughs Wellcome Fund , the Crohn's & Colitis Foundation , Cure for IBD , and the Rosanne H. Silberman Foundation . H.N. was supported by the JSPS Research Fellowship for Japanese Biomedical and Behavioral Researchers at NIH. T.M. was supported by the Crohn{\textquoteright}s & Colitis Foundation. Funding Information: We thank members of Molecular Immunology and Inflammation Branch (NIAMS) for input and support. We thank S. Dell'Orso, G. Gutierrez-Cruz, and F. Naz (Genome Analysis Core Facility, NIAMS); J. Simone, J. Lay, and K. Tinsley (Flow Cytometry Section, NIAMS); H-W. Sun and S.R. Brooks (Biodata Mining and Discovery Section, NIAMS); E. Ralston and A. Kenea (Light Imaging Section, NIAMS); and L. Samsel and P. J. McCoy (Flow Cytometry Core, NHLBI) for their technical support. This study utilized the high-performance computational capabilities of the Biowulf Linux cluster at the NIH. This work was supported by the Intramural Research Programs of NIAMS and NIAID. Research in the Artis laboratory is supported by the National Institutes of Health (AI074878, AI095466, AI095608, and AI102942), the Burroughs Wellcome Fund, the Crohn's & Colitis Foundation, Cure for IBD, and the Rosanne H. Silberman Foundation. H.N. was supported by the JSPS Research Fellowship for Japanese Biomedical and Behavioral Researchers at NIH. T.M. was supported by the Crohn's & Colitis Foundation. H.N. and T.M. designed the project and performed and analyzed experiments with assistance and advice from H.-Y.S. F.P.D. F.M. Y.H. O.J.H. C.Y. and Y.M. H.-Y.S. performed and analyzed ATAC-seq. F.P.D. performed computational analysis. J.F.U. and K.M.C. contributed to analytical tools and input regarding experimental design. K.M.C. Y.B. D.A. Y.K. and J.J.O. planned and supervised this project. H.N. T.M. D.A. Y.K. and J.J.O. wrote the manuscript with input, advice, and revisions from all authors. D.A. has contributed to scientific advisory boards at MedImmune, Pfizer, FARE, and the KRF. Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = oct,
day = "15",
doi = "10.1016/j.immuni.2019.06.009",
language = "English",
volume = "51",
pages = "682--695.e6",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}
