Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

Yu Mimura, Hana Nishida, Shinichiro Nakajima, Sakiko Tsugawa, Shinji Morita, Kazunari Yoshida, Ryosuke Tarumi, Kamiyu Ogyu, Masataka Wada, Shin Kurose, Takahiro Miyazaki, Daniel M. Blumberger, Zafiris J. Daskalakis, Robert Chen, Masaru Mimura, Yoshihiro Noda

研究成果: Review article査読

抄録

Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include short- and long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.

本文言語English
ページ(範囲)47-59
ページ数13
ジャーナルNeuroscience and Biobehavioral Reviews
121
DOI
出版ステータスPublished - 2021 2

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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