TY - GEN
T1 - Neurospheroid array on a flexible substrate for cortical microstimulation
AU - Okita, Keisuke
AU - Kato-Negishi, Midori
AU - Onoe, Hiroaki
AU - Takeuchi, Shoji
PY - 2013/4/2
Y1 - 2013/4/2
N2 - This paper describes a centimeter-sized flexible multi-electrode array (MEA) integrated with a neuronal spheroid (neurospheroid) array. The MEA has a number of neurospheroids and can be applied to extensively curved surfaces (e.g., brain). We demonstrated that MEA successfully activated neurons within a neurospheroid on the microelectrode array. In addition, the MEA was used to activate 2D culture of cortical cells through the neurospheroids. These results mark an important step toward achieving minimally-invasive cortical microstimulation via neurospheroid-based stimulating systems.
AB - This paper describes a centimeter-sized flexible multi-electrode array (MEA) integrated with a neuronal spheroid (neurospheroid) array. The MEA has a number of neurospheroids and can be applied to extensively curved surfaces (e.g., brain). We demonstrated that MEA successfully activated neurons within a neurospheroid on the microelectrode array. In addition, the MEA was used to activate 2D culture of cortical cells through the neurospheroids. These results mark an important step toward achieving minimally-invasive cortical microstimulation via neurospheroid-based stimulating systems.
UR - http://www.scopus.com/inward/record.url?scp=84875474541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875474541&partnerID=8YFLogxK
U2 - 10.1109/MEMSYS.2013.6474217
DO - 10.1109/MEMSYS.2013.6474217
M3 - Conference contribution
AN - SCOPUS:84875474541
SN - 9781467356558
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 221
EP - 224
BT - IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
T2 - IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Y2 - 20 January 2013 through 24 January 2013
ER -