Neurotrophic activity in cytokine-activated astrocytes

Kazunari Yoshida, Shigeo Toya

研究成果: Review article

21 引用 (Scopus)


Accumulating evidence indicates that various neurotrophic factors (NTFs) exist and function in the brain. In the mature mammalian brain, NTF expression is exclusively restricted to neurons. However, astrocytes activated by various cytokines, including fibroblast growth factor and interleukin-1̄, produce a significant amount of nerve growth factor (NGF) in vitro. Furthermore, non-NGF type NTF expression in astrocytes is also activated by the cytokines. The cytokines also enhance both release of ciliary neurotrophic factor from and expression of high-molecular weight basic fibroblast growth factor (FGF) in astrocytes. In the early phase following brain injury, cytokine-activated astrocytes rescue the damaged neurons via NTFs and other biologically active molecules.

ジャーナルKeio Journal of Medicine
出版物ステータスPublished - 1997 6

ASJC Scopus subject areas

  • Medicine(all)

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