Neurotrophic activity in cytokine-activated astrocytes

Kazunari Yoshida, Shigeo Toya

研究成果: Article

21 引用 (Scopus)

抄録

Accumulating evidence indicates that various neurotrophic factors (NTFs) exist and function in the brain. In the mature mammalian brain, NTF expression is exclusively restricted to neurons. However, astrocytes activated by various cytokines, including fibroblast growth factor and interleukin-1̄, produce a significant amount of nerve growth factor (NGF) in vitro. Furthermore, non-NGF type NTF expression in astrocytes is also activated by the cytokines. The cytokines also enhance both release of ciliary neurotrophic factor from and expression of high-molecular weight basic fibroblast growth factor (FGF) in astrocytes. In the early phase following brain injury, cytokine-activated astrocytes rescue the damaged neurons via NTFs and other biologically active molecules.

元の言語English
ページ(範囲)55-60
ページ数6
ジャーナルKeio Journal of Medicine
46
発行部数2
出版物ステータスPublished - 1997 6

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Nerve Growth Factors
Astrocytes
Cytokines
Ciliary Neurotrophic Factor
Neurons
Fibroblast Growth Factor 1
Brain
Nerve Growth Factor
Fibroblast Growth Factor 2
Interleukin-1
Brain Injuries
Intercellular Signaling Peptides and Proteins
Molecular Weight

ASJC Scopus subject areas

  • Medicine(all)

これを引用

Neurotrophic activity in cytokine-activated astrocytes. / Yoshida, Kazunari; Toya, Shigeo.

:: Keio Journal of Medicine, 巻 46, 番号 2, 06.1997, p. 55-60.

研究成果: Article

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