Neutrophil elastase and elastin-derived peptides in BAL fluid and emphysematous changes on CT scans

T. Betsuyaku, M. Nishimura, A. Yoshioka, K. Takeyabu, K. Miyamoto, Y. Kawakami

研究成果: Article査読

10 被引用数 (Scopus)

抄録

We examined the relationship between neutrophil elastase, elatin- derived peptides in bronchoalveolar lavage (BAL) fluid, and the development of pulmonary emphysema. The level of neutrophil elastase was higher in asymptomatic current smokers with emphysematous changes on computed tomographic scans than in current smokers without emphysematous changes, and was found to be correlated with the level of elastin-derived peptides in BAL fluid. Subjects with high levels of neutrophil elastase in BAL fluid had faster annual declines in FEV1. We conclude that the level of neutrophil elastase in BAL fluid can be used to differentiate asymptomatic cigarette smokers who are at risk for pulmonary emphysema from those who are not.

本文言語English
ページ(範囲)69-74
ページ数6
ジャーナルJapanese Journal of Thoracic Diseases
34
SUPPL.
出版ステータスPublished - 1996 12 1

ASJC Scopus subject areas

  • 呼吸器内科

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