抄録
The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 795-797 |
| ページ数 | 3 |
| ジャーナル | Natural Product Communications |
| 巻 | 11 |
| 発行部数 | 6 |
| 出版物ステータス | Published - 2016 6 1 |
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ASJC Scopus subject areas
- Medicine(all)
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine
これを引用
New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood. / Sugiyama, Takuji; Narukawa, Yuuji; Shibata, Shunsuke; Masui, Ryo; Kiuchi, Fumiyuki.
：: Natural Product Communications, 巻 11, 番号 6, 01.06.2016, p. 795-797.研究成果: Article
}
TY - JOUR
T1 - New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood
AU - Sugiyama, Takuji
AU - Narukawa, Yuuji
AU - Shibata, Shunsuke
AU - Masui, Ryo
AU - Kiuchi, Fumiyuki
PY - 2016/6/1
Y1 - 2016/6/1
N2 - The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
AB - The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
UR - http://www.scopus.com/inward/record.url?scp=84989204388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84989204388&partnerID=8YFLogxK
M3 - Article
C2 - 27534119
AN - SCOPUS:84989204388
VL - 11
SP - 795
EP - 797
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 6
ER -