抜粋
The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6, 8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6, 7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 795-797 |
| ページ数 | 3 |
| ジャーナル | Natural product communications |
| 巻 | 11 |
| 発行部数 | 6 |
| DOI | |
| 出版物ステータス | Published - 2016 1 1 |
ASJC Scopus subject areas
- Pharmacology
- Plant Science
- Drug Discovery
- Complementary and alternative medicine
フィンガープリント New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。
これを引用
Sugiyama, T., Narukawa, Y., Shibata, S., Masui, R., & Kiuchi, F. (2016). New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood. Natural product communications, 11(6), 795-797. https://doi.org/10.1177/1934578x1601100624