New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood

Takuji Sugiyama, Yuuji Narukawa, Shunsuke Shibata, Ryo Masui, Fumiyuki Kiuchi

研究成果: Article

2 引用 (Scopus)

抄録

The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6,8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6,7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.

元の言語English
ページ(範囲)795-797
ページ数3
ジャーナルNatural Product Communications
11
発行部数6
出版物ステータスPublished - 2016 6 1

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Type 3 Cyclic Nucleotide Phosphodiesterases
chemical derivatives
extracts
Chromones
inhibitory concentration 50
fractionation
Fluorescence Polarization
fluorescence
Inhibitory Concentration 50
2-(2-phenylethyl)chromone
methodology

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

これを引用

New 2-(2-Phenylethyl)chromone Derivatives and Inhibitors of Phosphodiesterase (PDE) 3A from Agarwood. / Sugiyama, Takuji; Narukawa, Yuuji; Shibata, Shunsuke; Masui, Ryo; Kiuchi, Fumiyuki.

:: Natural Product Communications, 巻 11, 番号 6, 01.06.2016, p. 795-797.

研究成果: Article

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