TY - JOUR
T1 - New 2-(2-phenylethyl)chromone derivatives and inhibitors of phosphodiesterase (PDE) 3A from Agarwood
AU - Sugiyama, Takuji
AU - Narukawa, Yuji
AU - Shibata, Shunsuke
AU - Masui, Ryo
AU - Kiuchi, Fumiyuk
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6, 8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6, 7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
AB - The MeOH extract of agarwood showed inhibitory activity against phosphodiesterase (PDE) 3A. Fractionation of the extract led to the isolation of two new 2-(2-phenylethyl)chromones, 6, 8-dihydroxy-2-[2-(4'-methoxyphenyl)ethyl]chromone (6), and 6, 7-dihydroxy-2-(2-phenylethyl)chromone (8), together with six known compounds. All isolated compounds were tested for their PDE 3A inhibitory activity using fluorescence polarization method. Compound 7 showed PDE 3A inhibitory activity with IC50 of 4.83 μM.
KW - 2-(2-Phenylethyl)chromone
KW - Agarwood
KW - Phosphodiesterase inhibitor
UR - http://www.scopus.com/inward/record.url?scp=84989204388&partnerID=8YFLogxK
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U2 - 10.1177/1934578x1601100624
DO - 10.1177/1934578x1601100624
M3 - Article
C2 - 27534119
AN - SCOPUS:84989204388
VL - 11
SP - 795
EP - 797
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 6
ER -